• Evakion has created genetic adjuvant technologies that enhances the immune response to viral, bacterial and cancer vaccines.
  • Preclinically validated for DNA and mRNA vaccines and prepared for clinical testing
  • Anticipated huge industry prospective for DNA and mRNA vaccines against cancer, viral and bacterial ailments

COPENHAGEN, Denmark, Might 25, 2023 (GLOBE NEWSWIRE) — Evakion Biotecһ A/S (NASDAQ: EVAKS) (“Evakion” or the “Firm”), a clinical-stage biotechnology firm specializing in the discovery and improvement of AI-immunotherapy, right now unveils the technologies behind its new proprietary genetic adjuvant created to increase the efficacy of DNA and mRNA vaccines for infectious ailments and cancer.

The most recent information from the adjuvant system have been presented at Evakion’s reside R&D day on Might 25, 2023.

“We are excited to introduce this new gene-assisted technologies to the international scientific neighborhood.” It amplifies Evakion’s proprietary DNA technologies and has the prospective to improve the impact of practically any vaccine. We foresee wonderful industry prospective as this technologies seems to be extremely helpful in DNA and mRNA primarily based vaccines against cancer as nicely as infectious ailments. stated Per Norlen, CEO of Evakion.

Evakion’s new genetic adjuvant carries the code for CCL19, a molecule recognized to attract immune cells, specifically antigen-presenting cells, and can be encoded into the DNA or mRNA of vaccines to increase the immune response.

Current information show that genetic adjuvant technologies enhances the antitumor impact in preclinical tumor models and induces neutralizing antibodies and T-cell responses against viral and bacterial antigens:

  • Delivery of DNA or mRNA neoantigen cancer vaccines elicited robust neoantigen-particular T-cell responses and full antitumor responses
  • Delivery of a T-cell epitope DNA vaccine of COVID-19 resulted in a robust and particular T-cell response and protected against a lethal dose of virus (90% survival)
  • Delivery a Neisseria Gonorrhoeae antigenic DNA vaccine elicited higher antibody titers and particular T-cell responses to bacterial antigens
  • Per Norlen continues, “By encoding the immunostimulatory molecule CCL19 into vaccine DNA or mRNA, we demonstrated a important improvement in vaccine efficacy. We think this advance has tremendous prospective for vaccine improvement, as it boosts B-cell and T-cell immune responses, generating it applicable to a wide variety of vaccines. Constructing on the encouraging preclinical outcomes, the subsequent step is to validate the technologies in sufferers.

    Evakion aims to bring the gene-assisted technologies into clinical trials later this year as component of the EVKS-03 customized cancer immunotherapy system.

    Stop by the Investors section of Evakion’s web-site to access a replay of the R&D Day presentations.

    About Evakion

    Evakion Biotech A/S is a pioneering firm establishing immunotherapies powered by artificial intelligence. Evakion’s proprietary and scalable AI technologies decode the human immune technique to uncover and create new immunotherapies for cancer, bacterial ailments and viral infections. Evakion has a wide variety of candidates, which includes 3 customized cancer immunotherapies. Positioned in Hørsholm, Denmark, with 50 workers and listed on the Nasdaq New York Stock Exchange. For far more facts, stop by www.evakion-biotech.com.

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